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  • Title: Plasma radioiron kinetics in man: explanation for the effect of plasma iron concentration.
    Author: Skarberg K, Eng M, Huebers H, Marsaglia G, Finch C.
    Journal: Proc Natl Acad Sci U S A; 1978 Mar; 75(3):1559-61. PubMed ID: 274740.
    Abstract:
    The plasma iron turnover was measured in 19 normal subjects. A correlation was found between plasma iron concentration and plasma iron turnover. In addition to the turnover of 55Fe at normal plasma iron concentration (predominantly monoferric transferrin), a second turnover in which the labeled plasma was saturated with iron (to produce predominantly diferric transferrin) was studied with 50Fe. It was demonstrated that diferric transferrin had a greater rate of iron turnover but that the distribution between erythroid and non-erythroid tissues was unchanged. It was concluded that plasma iron turnover is dependent on the monoferric/diferric transferrin ratio in the plasma but that the internal distribution of iron is unaffected.
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