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  • Title: A convenient synthesis and screening of benzosuberone bearing 1,2,3-triazoles against Mycobacterium tuberculosis.
    Author: Sajja Y, Vanguru S, Jilla L, Vulupala HR, Bantu R, Yogeswari P, Sriram D, Nagarapu L.
    Journal: Bioorg Med Chem Lett; 2016 Sep 01; 26(17):4292-5. PubMed ID: 27476139.
    Abstract:
    A series of benzosuberone bearing 1,2,3-triazoles were rationally designed and alkyl/aryl groups appended on 1,2,3-triazole derivatives 5a-o were synthesized using click chemistry and evaluated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC27294). Compounds 5h (MIC: 3.125μg/mL) and 5l, 5m, 5o (MIC: 6.25μg/mL) exhibited promising hits. This is the first Letter on the synthesis and in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv of benzosuberone alkyl/aryl groups appended on 1,2,3-triazole derivatives.
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