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  • Title: [Detection of viral antigens in the lungs and spleen of mice infected with influenza virus].
    Author: Ivanova IA, Meringova LF, Dubrovina TIa.
    Journal: Mol Gen Mikrobiol Virusol; 1989 May; (5):39-45. PubMed ID: 2747703.
    Abstract:
    The data are presented on the possibility of using the dot immunosorption technique for identification of influenza viral antigens in the tissues of infected animal in course of infection. The possibility of quantitative evaluation of the viral antigen contents in the tissues of infected animal permits to use the technique for evaluation of dynamics and rate of viral antigens excretion in course of infection. The information might be useful for studying the pathogenicity of influenza as well as for evaluation of efficiency of immunocorrecting and antiviral preparations. Auxiliary analysis of antigen-containing material by immunoblotting technique has confirmed the viral nature of identified polypeptides. In the future the proposed method may be used to study the viral antigenic structure in infected tissues dependent of the location and time of viral antigens isolation.
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