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  • Title: Cytogenetic effects of 3,4-dichloroaniline in human lymphocytes and V79 Chinese hamster cells.
    Author: Bauchinger M, Kulka U, Schmid E.
    Journal: Mutat Res; 1989 Jul; 226(3):197-202. PubMed ID: 2747732.
    Abstract:
    3,4-Dichloroaniline (3,4-DCA), an intermediate in various chemical syntheses, has been detected as an environmental contaminant in surface waters and in the effluents from dye-manufacturing plants. Tested for clastogenicity in human lymphocytes in vitro the compound was inactive in the chromosome aberration assay yet exhibited a positive sister-chromatid exchange response in the presence of a mammalian metabolic activation system. Exposure of V79 Chinese hamster cells to 3,4-DCA caused a concentration-dependent increase in the incidence of spindle disturbances, predominantly of the initial c-mitotic type. The results indicate that 3,4-DCA might induce aneuploidy in mammalian cells by interaction with the mitotic apparatus.
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