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  • Title: [Current flora of mandibular osteomyelitis].
    Author: Deffez JP, Lambert-Zechovsky N, Brethaux J, Goubert L.
    Journal: Rev Stomatol Chir Maxillofac; 1977; 78(7):465-76. PubMed ID: 274792.
    Abstract:
    1) Blood-borne osteomyelitis may have a dental portal of entry. This results in a bacteraemia or septicaemia due to organisms other than staphylococci. In such cases, osseous lesions occur at a distance from the initial dental site. 2) As far as antibiotic treatment is concerned:--It must be begun early but not prematurely, i.e. bacteriological studies should be undertaken before antibotic therapy is started, possibly to be later changed in the light of laboratory results.--It should be combined, with a preference for two antibiotics which result in a bactericidal combination, as soon as the responsible organism is identified.--It should be given in high dosage, in view of the problem of diffusion of the antibiotic to the centre of the necrotic bone lesion.--It should be prolonged, based upon clinical, laboratory and radiological findings.
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