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  • Title: Ionofore antibiotic polynactin produced by Streptomyces sp. 156A isolated from Lake Baikal.
    Author: Shishlyannikova TA, Kuzmin AV, Fedorova GA, Shishlyannikov SM, Lipko IA, Sukhanova EV, Belkova NL.
    Journal: Nat Prod Res; 2017 Mar; 31(6):639-644. PubMed ID: 27486824.
    Abstract:
    The potential antibacterial activity of secondary metabolites produced by Streptomyces sp. 156A isolated from Lake Baikal was investigated. The selective liquid-liquid extraction method was applied to obtain a mixture of nactins (polynactin) produced by the strain. The polynactin consisted of nonactin (3%), monactin (18%), dinactin (36%), trinactin (31%) and tetranactin (12%). The compounds were identified by MS/MS, 1H and 13C NMR methods. The loss of neutral 184 and 198 Da fragments from a sodiated molecular ion, [M + Na]+, of nactins was observed in the MS/MS spectrum. The polynactin was shown to possess the antibiotic activity against Gram-positive strains including opportunistic strains and strains isolated from various ecosystems of Lake Baikal.
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