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  • Title: [Effectiveness and tolerance of amoxicillin/clavulanic acid ("Augmentin") in intravenous injections in adults].
    Author: el Filali KM, el M'Daghri N, el Kabli H, Hajji M, Benbachir M, Himmich H.
    Journal: Pharmatherapeutica; 1989; 5(5):329-37. PubMed ID: 2748691.
    Abstract:
    A prospective study was carried out in 43 hospitalized patients with respiratory or other serious bacterial infections requiring intravenous antibiotic therapy to assess the efficacy and tolerance of amoxycillin/clavulanic acid ('Augmentin'). After bacteriological and laboratory investigations patients were started on 1 g amoxycillin plus 200 mg clavulanic acid intravenously every 8 hours for the first 3 days and then were treated orally at the same dosage. Duration of treatment varied according to the type and severity of the infection, with a minimum of 10 days. Efficacy of treatment was evaluated by the clinical response, judged by the resolution of signs and symptoms of infection. The results showed that there was a clinical cure rate of 88.4%. Local tolerance was excellent and there were few side-effects reported. Six patients experienced vomiting which led to the withdrawal of treatment in 1 patient.
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