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  • Title: The value of cerebrospinal fluid cytology in the early diagnosis of metasttatic retinoblastoma.
    Author: Greenberg ML, Goldberg L.
    Journal: Acta Cytol; 1977; 21(6):735-8. PubMed ID: 274881.
    Abstract:
    The cytomorphologic features of exfoliated retinoblastoma cells in CSF processed by a simple micropore filter technique has been described. The role of CSF cytology in the early identification of metastatic retinoblastoma cells, with its influence on treatment and prognosis, is stressed. Retinoblastoma cells in CSF are characteristically small with scanty or absent cytoplasm and hyperchromatic irregular nuclei which tend to be moulded. These cells generally occur singly or aggregated into clusters of various sizes but are seldom seen in typical rosette formation.
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