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  • Title: Rat blood and brain amino acid pattern in short term experimental diabetes.
    Author: Atienza G, Aldegunde M, Veira JA, Lorenzo A, Conejero R.
    Journal: Rev Esp Fisiol; 1989 Mar; 45(1):15-20. PubMed ID: 2748974.
    Abstract:
    Some serum and brain amino acid variations occurring in animals with short term streptozotocin-diabetes (24 h) are studied in this work. Diabetic animals showed an increase in serum of the three branched-chain amino acids as well as an increase in free tryptophan, besides a decrease in total serum tryptophan and in the tryptophan/competitor amino acids ratio. In brain, the three branched-chain amino acids increased, but there were no variation in whole brain tryptophan. Nevertheless, by studying levels of tryptophan in different brain regions, an increase in medulla-pons was recorded. This circumstance could be explained by the increase in free serum tryptophan levels, in agreement with several authors who assign this reason for brain tryptophan.
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