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  • Title: A comparison of the hypotensive effects of Met-enkephalin in normotensive and spontaneously hypertensive rats.
    Author: Nomura S, Mizutani S, Kurauchi O, Furuhashi M, Kasugai M, Narita O, Tomoda Y.
    Journal: Res Commun Chem Pathol Pharmacol; 1989 Apr; 64(1):169-72. PubMed ID: 2748999.
    Abstract:
    To elucidate the role of Met-enkephalin in the hypertension in spontaneously hypertensive rats, the depressor response to Met-enkephalin was compared between normotensive (Wistar) and spontaneously hypertensive rats by administration of bestatin (1.25 mg) as a component of a mixture of enkephalinase inhibitors. All experiments were performed under anesthesia by intraperitoneal injection of pentobarbital (50mg/kg). Catheters were connected to the arterial and venous lines for blood pressure recording and administration of drugs. Hypotensive effects of injected Met-enkephalin were noticeably enhanced by administration of bestatin compared with pre-bestatin responses at each dose of Met-enkephalin(10, 25, 50, and 100n mol). We could not find any statistically significant difference between blood pressure responses to 25n mole Met-enkephalin in Wistar and spontaneously hypertensive rats both before and after administration of bestatin. Our present study dose not suggest the active role of Met-enkephalin in the hypertension of spontaneously hypertensive rats.
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