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  • Title: Synthesis, antimicrobial activity and advances in structure-activity relationships (SARs) of novel tri-substituted thiazole derivatives.
    Author: Reddy GM, Garcia JR, Reddy VH, de Andrade AM, Camilo A, Pontes Ribeiro RA, de Lazaro SR.
    Journal: Eur J Med Chem; 2016 Nov 10; 123():508-513. PubMed ID: 27494167.
    Abstract:
    Trisubstituted thiazoles were synthesized and studied for their antimicrobial activity and supported by theoretical calculations. In addition, MIC, MBC and MFC were also tested. Moreover, the present study was analyzed to scrutinize comprehensive structure-activity relationships. In fact, LUMO orbital energy and orbital orientation was reliable to explain their antibacterial and antifungal assay. Amongst the tested compounds, tri-methyl-substituted thiazole compound showed higher antimicrobial activity and low MIC value due to highest LUMO energy.
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