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  • Title: Use of panel testing for detection of antinuclear antibody in a resource-limited setting: an appraisal.
    Author: Minz RW, Kumar Y, Saikia B, Anand S, Varma S, Singh S.
    Journal: Postgrad Med; 2016 Nov; 128(8):869-874. PubMed ID: 27494797.
    Abstract:
    OBJECTIVES: Despite an increase in the incidence of systemic connective tissue diseases (CTD), panel testing for detection of antinuclear antibodies (ANA) is not a routine practice in many health centers of the Indian subcontinent. Consequently, the data on its significance is scanty. METHODS: To evaluate utility of panel testing, line immunoassay (LIA) and indirect immunofluorescence antinuclear antibody test (IIF-ANA) were performed in 321 cases of CTD. RESULTS: Out of 321 serum samples screened by the above tests, 227 were positive and 18 were negative by both LIA and IIF-ANA. Additional 11/321 (3.4%) cases were picked up by LIA. SSA was most common specificity in these cases followed by SSA/SSB, SSB, Ro-52, Jo-1, dsDNA and nRNP/Sm. CONCLUSION: Use of LIA along with IF-ANA and ELISA improves sensitivity of CTD screening.
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