These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The dependence of the carcinogenic effect on the concentration of N-nitrosodiethylamine].
    Author: Voronin VM, Litvinov NN, Kazachkov VI, Shamarin AA, Zhurkov VS.
    Journal: Vopr Onkol; 1989; 35(6):685-9. PubMed ID: 2750080.
    Abstract:
    In a 86-week-long experiment using 1087 mice (487 hybrids and 600 non-inbred animals), the concentration-effect relationship was studied for N-nitrosodiethylamine (NDEA) given in drinking water. NDEA concentrations of 0.08; 0.4; 2.0 and 10.0 mg/l produced tumors in male and female hybrids with the frequencies of 35.9/30.9, 49.9/43.6, 61.9/72.3 and 81.8/82.9%, respectively (20.0.20.0% in controls) whereas in non-inbred animals the frequencies were 15.6/34.2, 24.2/33.3, 35.9/57.1 and 78.4/80.9%, respectively (15.0/30.0% in controls). The "minimal effective" carcinogenic level of NDEA proved 0.4 mg/l for hybrids and 2.0 mg/l for non-inbred mice (P less than 0.05). No sex differences were found for frequency or histologic pattern of tumor. The data obtained can be used in calculating sanitary-hygienic standards for NDEA.
    [Abstract] [Full Text] [Related] [New Search]