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  • Title: [Emotional manifestations in the electrical stimulation of the hypothalamic nuclei in adult and old rats].
    Author: Rushkevich IuE.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1989; 39(2):273-7. PubMed ID: 2750287.
    Abstract:
    In experiments on adult (9-10 months) and old (24-26 months) white Wistar rats behavioural manifestations under electrical stimulation of the ventromedial hypothalamus nucleus and self-stimulation (SS) of the lateral hypothalamic region were studied. It has been found that with age electrical thresholds of negative emotional manifestations decrease with invariable SS thresholds. In old rats, in comparison with the adult ones, SS frequency is lower, maximum SS proceeds at lower currents, the range of currents capable to evoke an intensive SS is narrower, SS motivational component is less expressed. The obtained data testify that in old rats there exist neurophysiological preconditions for prevailing of negative emotional manifestations.
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