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  • Title: Activity of Cysteamine against the Cystic Fibrosis Pathogen Burkholderia cepacia Complex.
    Author: Fraser-Pitt D, Mercer D, Lovie E, Robertson J, O'Neil D.
    Journal: Antimicrob Agents Chemother; 2016 Oct; 60(10):6200-6. PubMed ID: 27503654.
    Abstract:
    There are no wholly successful chemotherapeutic strategies against Burkholderia cepacia complex (BCC) colonization in cystic fibrosis (CF). We assessed the impact of cysteamine (Lynovex) in combination with standard-of-care CF antibiotics in vitro against BCC CF isolates by the concentration at which 100% of bacteria were killed (MIC100) and checkerboard assays under CLSI standard conditions. Cysteamine facilitated the aminoglycoside-, fluoroquinolone- and folate pathway inhibitor-mediated killing of BCC organisms that were otherwise resistant or intermediately sensitive to these antibiotic classes. Slow-growing BCC strains are often recalcitrant to treatment and form biofilms. In assessing the impact of cysteamine on biofilms, we demonstrated inhibition of BCC biofilm formation at sub-MIC100s of cysteamine.
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