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  • Title: [Clinico-experimental research on the electrophysiological and polarographic characteristics of the cerebral cortex in hypoxia].
    Author: Chkhenkeli SA, Bregvadze ESh.
    Journal: Zh Vopr Neirokhir Im N N Burdenko; 1989; (2):17-23. PubMed ID: 2750395.
    Abstract:
    Electrocorticography, measurement of tissue PO2, local cerebral blood flow, and sodium ion concentration in the extracellular fluid of the cerebral cortex, as well as study of dynamics of the response of the cortex to its direct electrical stimulation, conducted during neurosurgical operations on patients with tumors of the brain and in experiment revealed two stages in the changes of excitability of the cortex: first stage--its sharp increase and second stage--its suppression. Electrophysiological and polarographic characteristics of these stages of edema and excitability of the cerebral cortex are shown. The results of the research are discussed from the standpoint of the pathomechanisms of the occurrence and cessation of epileptic seizures in the development of brain edema.
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