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  • Title: Efficacy of ciprofloxacin against Leptospira interrogans serogroup icterohaemorrhagiae.
    Author: Shalit I, Barnea A, Shahar A.
    Journal: Antimicrob Agents Chemother; 1989 May; 33(5):788-9. PubMed ID: 2751290.
    Abstract:
    Ciprofloxacin activity against Leptospira interrogans serogroup icterohaemorrhagiae was studied in vitro and in an animal model. The MBC of ciprofloxacin was 0.6 microgram/ml. Three of three Syrian hamsters died 8 to 9 days after intraperitoneal challenge with 10(6) leptospires. In contrast, five of six animals given ciprofloxacin 3 or 5 days after challenge survived.
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