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  • Title: α1-Antitrypsin Deficiency.
    Author: Hatipoğlu U, Stoller JK.
    Journal: Clin Chest Med; 2016 Sep; 37(3):487-504. PubMed ID: 27514595.
    Abstract:
    α1-Antitrypsin deficiency is an autosomal codominant condition that predisposes to emphysema and cirrhosis. The condition is common but grossly under-recognized. Identifying patients' α1-antitrypsin deficiency has important management implications (ie, smoking cessation, genetic and occupational counseling, and specific treatment with the infusion of pooled human plasma α1-antitrypsin). The weight of evidence suggests that augmentation therapy slows the progression of emphysema in individuals with severe α1-antitrypsin deficiency.
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