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  • Title: [Synthesis of 5'-phosphorylated oligodeoxyribonucleotides by the H-phosphonate method].
    Author: Filippov SA, Esipov DS, Kalinichenko SV, Dobrynin VN.
    Journal: Bioorg Khim; 1989 Apr; 15(4):527-9. PubMed ID: 2751710.
    Abstract:
    N,O-protected 2'-deoxyribonucleotide-3'-H-phosphonates and 2-(p-nitrophenylethyl)-H-phosphonate were prepared and used in solid-phase synthesis of 5'-phosphorylated DNA. H-Phosphonate condensation is performed with 1:2 ratio of P-component to activator (pivaloyl chloride). Protection groups were removed either by sequential treatment with conc. NH3 and DBU or by combination of these reagents.
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