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  • Title: Ca2+-dependent regulation of the dynamic polarity of F-actin under the influence of tropomyosin and troponin.
    Author: Mihashi K, Suzuki N, Ooi A.
    Journal: Biophys Chem; 1989 May; 33(2):195-204. PubMed ID: 2752094.
    Abstract:
    A novel method that we have developed in the preceding paper to study the subunit exchange rates of F-actin (N. Suzuki and K. Mihashi, Biophys. Chem. 33 (1989) 177) was applied to regulated F-actin (a complex of F-actin, tropomyosin and troponin). We found that the dynamic polarity of regulated F-actin is modulated in a Ca2+-dependent manner, giving rise to strong suppression of the on/off rates of subunit exchange at the P-end. We interpreted this characteristic suppression as follows. Removal of Ca2+ from troponin C in regulated F-actin produces strong constraints on fluctuations in potential energy of an intermediate conformation of the terminal structure (P-end) which would be formed in the course of association and dissociation of the actin subunit.
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