These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Tributyltin chloride induces renal dysfunction by inflammation and oxidative stress in female rats.
    Author: Coutinho JV, Freitas-Lima LC, Freitas FF, Freitas FP, Podratz PL, Magnago RP, Porto ML, Meyrelles SS, Vasquez EC, Brandão PA, Carneiro MT, Paiva-Melo FD, Miranda-Alves L, Silva IV, Gava AL, Graceli JB.
    Journal: Toxicol Lett; 2016 Oct 17; 260():52-69. PubMed ID: 27521499.
    Abstract:
    Tributyltin chloride (TBT) is an organometallic pollutant that is used as a biocide in antifouling paints. TBT induces several toxic and endocrine-disrupting effects. However, studies evaluating the effects of TBT on renal function are rare. This study demonstrates that TBT exposure is responsible for improper renal function as well as the development of abnormal morphophysiology in mammalian kidneys. Female rats were treated with TBT, and their renal morphophysiology was assessed. Morphophysiological abnormalities such as decreased glomerular filtration rate and increased proteinuria levels were observed in TBT rats. In addition, increases in inflammation, collagen deposition and α-smooth muscle actin (α-SMA) protein expression were observed in TBT kidneys. A disrupted cellular redox balance and apoptosis in kidney tissue were also observed in TBT rats. TBT rats demonstrated reduced serum estrogen levels and estrogen receptor-α (ERα) protein expression in renal cortex. Together, these data provide in vivo evidence that TBT is toxic to normal renal function and that these effects may be associated with renal histopathology complications, such as inflammation and fibrosis.
    [Abstract] [Full Text] [Related] [New Search]