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  • Title: Neurotensin-induced polydipsia: a structure-activity study.
    Author: Hawkins MF, Baker JD, Baumeister AA.
    Journal: Brain Res; 1989 May 15; 487(1):188-91. PubMed ID: 2752285.
    Abstract:
    Neurotensin (NT) and equimolar concentrations of NT fragments were microinjected into the lateral cerebral ventricle of water-deprived rats. NT (10 micrograms) increased water intake 146% in the first 15 min following injection. While NT1-11 and NT10-13 had no effect on water intake, NT8-13 increased water intake 101%. The polydipsia produced by NT8-13 was statistically equivalent to that produced by NT. The results are discussed in relation to a proposed model of the NT receptor.
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