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  • Title: Biomimetic mineralization of nano-sized, needle-like hydroxyapatite with ultrahigh capacity for lysozyme adsorption.
    Author: Ma Y, Zhang J, Guo S, Shi J, Du W, Wang Z, Ye L, Gu W.
    Journal: Mater Sci Eng C Mater Biol Appl; 2016 Nov 01; 68():551-556. PubMed ID: 27524053.
    Abstract:
    Because of its superior biocompatibility, hydroxyapatite (HA) has been widely exploited as a promising vehicle to deliver a broad range of therapeutics in a variety of biological systems. Herein, we report a biomimetic process to prepare nano-sized, colloidal stable HA with needle-like morphology by using carboxymethyl cellulose (CMC) as the template. It was revealed that the needle-like HA was transformed from the spherical amorphous calcium phosphate (ACP) nanoparticles after a 14-day period of aging under ambient conditions. The needle-like HA/CMC exhibited an ultra-high lysozyme adsorption capacity up to 930-940mg/g. Moreover, a sustained and pH-sensitive release of adsorbed lysozyme from HA/CMC was evidenced. Therefore, our biomimetic needle-like HA/CMC nanoparticles hold great potential in serving as an efficient carrier for the delivery and controlled release of lysozyme.
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