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  • Title: Amoxycillin/clavulanic acid (Augmentin)-induced intrahepatic cholestasis.
    Author: Dowsett JF, Gillow T, Heagerty A, Radcliffe M, Toadi R, Isle I, Russell RC.
    Journal: Dig Dis Sci; 1989 Aug; 34(8):1290-3. PubMed ID: 2752877.
    Abstract:
    A 75-year-old man developed a biopsy-proven, drug-induced intrahepatic cholestasis after use of amoxycillin trihydrate combined with the beta-lactam inhibitor potassium clavulanate (Augmentin). Cholestatic liver injury is an uncommonly recognized, probably immunologically based adverse reaction to therapy with penicillin and its derivatives.
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