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  • Title: In vitro sensitivity of normal and leukemic myeloid clonogenic cells to hyperthermia: absence of selective effect.
    Author: Marie JP, Thevenin D, Zittoun R.
    Journal: Exp Hematol; 1989 Aug; 17(7):809-11. PubMed ID: 2753089.
    Abstract:
    The in vitro heat sensitivity of myeloid clonogenic cells was tested in 22 normal marrows (granulo-monocytic progenitors) and in 40 marrows of patients with acute myelogenous leukemia (leukemic progenitors). Cells were treated for 1 h at 42 degrees, 43 degrees, 44 degrees, or 45 degrees C prior to plating. A temperature-dependent inhibition of growth was seen without a selective effect on the two kinds of progenitors. Because these two kinds of progenitors have the same heat sensitivity, hyperthermia should not be used alone as a technique for in vitro depletion of residual myeloid leukemic cells.
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