These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Local conditions for global stability in the space of codons of the genetic code.
    Author: Salinas DG, Gallardo MO, Osorio MI.
    Journal: Biosystems; 2016 Dec; 150():73-77. PubMed ID: 27531459.
    Abstract:
    The polar requirement is an attribute of amino acids that is a major determinant of the structure and function of the proteins, and it plays a role in the flexibility and robustness of the genetic code. The viability of an organism depends on flexibility, which allows the exploration of new functions. However, robustness is necessary to protect the organism from deleterious changes derived from misreading errors and single-point mutations. Compared with random codes, the standard genetic code is one of the most robust against such errors. Here, using analytical and numerical calculations and the set of amino acid-encoding codons, we have proposed some local conditions that are necessary for the optimal robustness of the genetic code, and we explored the association between the local conditions and the robustness. The localness of the proposed conditions and the underlying evolutionary mechanism, which begins with a random code and progresses toward more efficient codes (e.g., the standard code), might be biologically plausible.
    [Abstract] [Full Text] [Related] [New Search]