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  • Title: Two New Oleanane-type Triterpenoids from Methanolyzed Saponins of Momordica cochinchinensis.
    Author: Fan R, Cheng RR, Zhu HT, Wang D, Yang CR, Xua M, Zhang YJ.
    Journal: Nat Prod Commun; 2016 Jun; 11(6):725-8. PubMed ID: 27534102.
    Abstract:
    Two new oleanane-type triterpenoid saponins (1 and 2) were isolated from the methanolyzed total saponins of the seeds of Momordica cochinchinensis (Lour.) Spreng, together with 16 known compounds (3-18). Their structures were elucidated on the basis of detailed spectroscopic, including 1D and 2D NMR, mass spectrometric, methanolysis and LC-MS analysis. All the isolates were tested for their cytotoxic activities against five human cancer cell lines (HL-60, SMMC-7721, PANC-1, A-549, and SW-480) and the glucose uptake activity. The known compound 6 exhibited toxic effects against HL-60 with an IC50 value of 18.1 μM, while 10 showed cytotoxicity against SMMC-7721 and A-549 cell lines, with IC50 values of 34.4 and 32.8 μM, respectively. In addition, the new compound 2 showed glucose uptake activity with a glucose consumption value of 0.29 μM at 10 μM concentration.
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