These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Retention characteristics in high-performance liquid chromatography of basic drugs and plasma extracts on an alumina column.
    Author: Kelly MT, Smyth MR, Dadgar D.
    Journal: J Chromatogr; 1989 Jun 28; 473(1):53-62. PubMed ID: 2753947.
    Abstract:
    The retention characteristics of 35 drugs on an alumina column using buffered aqueous methanolic mobile phases have been investigated. It has been shown that the effect of pH on retention depends on the pKa of the drug and the type of buffer ion used; that there is an inverse relation between ionic strength and solute retention; and that a decrease in the amount of methanol in the mobile phase causes the drugs to be held longer on the column. The chromatographic system was also coupled to an on-line column-switching assembly to facilitate extraction of the drugs from plasma, and results are presented which indicate that the alumina column lends itself well to this convenient method of plasma clean-up.
    [Abstract] [Full Text] [Related] [New Search]