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  • Title: Rheumatoid factor in patients with systemic lupus erythematosus.
    Author: Feldman D, Feldman D, Ginzler E, Kaplan D.
    Journal: J Rheumatol; 1989 May; 16(5):618-22. PubMed ID: 2754666.
    Abstract:
    One hundred sixty-six patients with systemic lupus erythematosus (SLE) were surveyed and their sera tested for the presence of rheumatoid factor (RF). Fifteen were positive whenever tested, with titers of at least 1:40; the remainder were either positive only in titers of 1:20, were inconsistently positive or were persistently negative. The former group were less likely to have severe manifestations of SLE, less likely to have required treatment with "high-dose" steroids or a cytotoxic drug, and less likely to have had an episode of herpes zoster. We conclude that in patients with SLE, RF may be a reflection of relative immune competence so that they are partially protected against the more serious manifestations of SLE and the development of herpes zoster.
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