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  • Title: [Thrombocytic hemostasis and the prostaglandin system at early stages of arterial hypertension].
    Author: Kolomiets VI, Babak OIa, Starchenko TG, Volos BE.
    Journal: Klin Med (Mosk); 1989 Apr; 67(4):82-5. PubMed ID: 2755063.
    Abstract:
    In young patients with borderline arterial hypertension the system of pressor and depressor prostaglandins (PG) is activated with maintenance of their physiological proportion. In patients with I stage essential hypertension a considerable rise in the level of PGF2 alpha and thromboxane determines the system imbalance in the direction of the predominance of pressor components. The platelet hemostatic link in I stage essential hypertension is characterized by an increase in platelet aggregation activity which is mediated by the imbalance of the prostacyclin-thromboxane system in the direction to thromboxane.
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