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  • Title: [Follow-up and prognosis of herpes simplex encephalitis. Observations on 57 patients between 1960 and 1987].
    Author: Huber M, Ziffling P, Heucke T, Heiss WD.
    Journal: Med Klin (Munich); 1989 Jun 15; 84(6):273-5. PubMed ID: 2755410.
    Abstract:
    A retrospective study of outcome in 57 herpes simplex encephalitis (HSE) patients treated between 1960 and 1987 is reported. HSE was confirmed by virus isolation or detection of intrathecal anti HSV synthesis. 24 patients did not receive antiviral therapy, 19 were vidarabine recipients and 14 were treated with acyclovir. Mortality was not correlated with sex or age but with the level of consciousness at onset of therapy. Acyclovir therapy was by far superior to vidarabine with respect both to mortality and neurologic sequelae after a mean follow-up period of 170 days.
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