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  • Title: p-Terphenyl Derivatives from the Endolichenic Fungus Floricola striata.
    Author: Li W, Gao W, Zhang M, Li YL, Li L, Li XB, Chang WQ, Zhao ZT, Lou HX.
    Journal: J Nat Prod; 2016 Sep 23; 79(9):2188-94. PubMed ID: 27557136.
    Abstract:
    Ten new p-terphenyl derivatives, floricolins A-J (1-10), together with six known compounds (11-16), were isolated from the extract of the endolichenic fungus Floricola striata. Chemical structures of these compounds were elucidated using spectroscopic data (HRESIMS and NMR). Among them, 9 and 10 were enantiomeric mixtures, and their configurations were established by single-crystal X-ray diffraction analysis using Cu Kα radiation. Evaluation of the isolated compounds against Candida albicans revealed that the most active compound, 3 (MIC 8 μg/mL), exerted fungicidal action by destruction of the cell membrane.
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