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  • Title: The link between callous-unemotional traits and neural mechanisms of reward processing: An fMRI study.
    Author: Veroude K, von Rhein D, Chauvin RJ, van Dongen EV, Mennes MJ, Franke B, Heslenfeld DJ, Oosterlaan J, Hartman CA, Hoekstra PJ, Glennon JC, Buitelaar JK.
    Journal: Psychiatry Res Neuroimaging; 2016 Sep 30; 255():75-80. PubMed ID: 27564545.
    Abstract:
    Callous-unemotional (CU) traits, i.e., unconcernedness and lack of prosocial feelings, may manifest in Conduct Disorder (CD), but also in Oppositional Defiant Disorder (ODD) and Attention Deficit Hyperactivity Disorder (ADHD). These disorders have been associated with aberrant reward processing, while the influence of CU traits is unclear. Using functional Magnetic Resonance Imaging (fMRI), we examined whether CU traits affect the neural circuit for reward. A Monetary Incentive Delay (MID) task was administered to 328 adolescents and young adults with varying levels of CU traits: 40 participants with ODD/CD plus ADHD, 101 participants with ADHD only, 84 siblings of probands with ADHD and 103 typically developing (TD) individuals. During reward anticipation, CU traits related negatively to medial prefrontal cortex (mPFC) activity, independent of ADHD symptoms and ODD/CD diagnosis. Our results indicate that CU traits are a valuable dimension for assessing the neural basis of reward processing.
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