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  • Title: Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines.
    Author: Bai ST, Zhu GL, Peng XR, Dong JR, Yu MY, Chen JC, Wan LS, Qiu MH.
    Journal: Molecules; 2016 Aug 26; 21(9):. PubMed ID: 27571056.
    Abstract:
    Three new triterpenoid alkaloids, namely buxmicrophyllines P-R (1-3), were isolated from the twigs and leaves of Buxus microphylla. Their structures were elucidated on the basis of NMR and MS spectroscopic analyses. Structurally, compounds 1-3 belong to the 9,10-cycloartane type alkaloids. In addition, compound 3 exhibited moderate cytotoxic activities in vitro against HL-60, SMMC-7221, A-549, MCF-7, and SW480 cell lines (with IC50 values ranging from 4.51 to 15.58 μM).
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