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  • Title: Jumping end-to-end dicentrics in a case of squamous cell carcinoma from a patient with xeroderma pigmentosum.
    Author: Aledo R, Aurias A, Avril MF, Dutrillaux B.
    Journal: Cancer Genet Cytogenet; 1989 Jul 01; 40(1):95-103. PubMed ID: 2758404.
    Abstract:
    Cytogenetic studies of a skin squamous cell carcinoma from a xeroderma pigmentosum patient were performed at several passages. They show the existence of recurrent rearrangements: 53% were dicentrics, of which 67% were of the telomere-telomere type. The telomeric region of the long arm of chromosome 12 was the most involved (in 38% of dicentrics), followed by 22p. The origin of this type of jumping rearrangement and its possible role on cell proliferation are discussed.
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