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  • Title: [Use of prostanoids in the diagnosis and treatment of bronchial reactivity in children].
    Author: Mrzena B, Tikovská J, Geier P.
    Journal: Cesk Pediatr; 1989 Jun; 44(6):331-3. PubMed ID: 2758489.
    Abstract:
    The bronchoconstrictive effect of prostaglandin F2 alpha was investigated in 24 school children suffering from obstructive lung disease. In all the investigated substance was administered by 2-minute inhalation, consecutively in doses of 0.06-0.12-0.25 and 0.5 mg with subsequent evaluation of pulmonary functions 1, 3, 6 and 10 minutes following inhalation. The trial was terminated when a drop of values indicating obstruction of the bronchial system by 20%, as compared with initial values, was recorded. While in healthy children the resistance of the air current did increase even after a high concentration of the administered substance, a provocation concentration in the patients was achieved already with the dose of 0.06 mg. The bronchodilating effect of prostaglandin E2 administered in a dose of 0.05 mg in eight asthmatic patients was very intensive but short and disappeared within 3 minutes after administration. From a therapeutic aspect the tussigenic effect of prostaglandin E2 played a more important role.
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