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  • Title: Inhibitory Components from Glycosmis stenocarpa on Pepper Mild Mottle Virus.
    Author: Kim JH, Yoon JY, Kwon SJ, Cho IS, Cuong NM, Choi SK, Kim YH, Choi GS.
    Journal: J Microbiol Biotechnol; 2016 Dec 28; 26(12):2138-2140. PubMed ID: 27586528.
    Abstract:
    The goal of this study was to identify a source of natural plant compounds with inhibitory activity against pepper mild mottle virus (PMMoV). We showed, using a half-leaf assay, that murrayafoline-A (1) and isomahanine (2) isolated from the aerial parts of Glycosmis stenocarpa have inhibitory activity against PMMoV through curative, inactivation, and protection effects. Using a leaf-disk assay, we confirmed that 2 inhibited virus replication in Nicotiana benthamiana. Using electron microscopy, we found that a mixture of the virus with 2 resulted in damage to the rod-shaped virus.
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