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  • Title: Scintigraphic quantitation of splenic function in SLE: correlation with IgM levels in serum.
    Author: Wilson WA, Perez MC, Marwah R, Foreman JB, McGrath H.
    Journal: Clin Exp Rheumatol; 1989; 7(3):251-5. PubMed ID: 2758705.
    Abstract:
    The relationship between quantitative splenic uptake of sulfur colloid and immunoglobulin M level in serum was studied in 15 patients with systemic lupus erythematosus (SLE). Splenic function correlated positively with IgM level (r = 0.58, p = 0.02) and inversely with antibody titre to n-DNA (r = -0.74, p = 0.003), and was reduced (p greater than 0.001) in patients with depressed IgM levels. IgM level in serum may be a useful correlate of splenic phagocytic function in SLE patients.
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