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  • Title: New macrocyclic lactones with acaricidal and nematocidal activities from a genetically engineered strain Streptomyces bingchenggensis BCJ60.
    Author: Li JS, Zhang H, Zhang SY, Wang HY, Zhang J, Chen AL, Wang JD, Xiang WS.
    Journal: J Asian Nat Prod Res; 2017 Apr; 19(4):339-346. PubMed ID: 27589571.
    Abstract:
    Two new macrocyclic lactones, 4,25-diethyl-4,25-demethyl-milbemycin β3 (1) and 27-formaldehyde-milbemycin β14 (2), were isolated from a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. The acaricidal and nematocidal capacities of compounds 1 and 2 were evaluated against Tetranychus cinnabarinus and Bursaphelenchus xylophilus, respectively. The results showed that the two new macrocyclic lactones 1 and 2 possessed potent acaricidal and nematocidal activities.
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