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  • Title: [Crohn disease--initial manifestation in the oral and anogenital area].
    Author: Gomez RS, Ozen IY, Peters KP, Simon M, Hornstein OP.
    Journal: Hautarzt; 1989 Jul; 40(7):451-5. PubMed ID: 2759861.
    Abstract:
    A case is reported of Crohn's disease in a 17-year-old patient. The initial manifestation was bipolar: the clinical features of macrocheilitis with swelling of the upper lip that had persisted for the last 6 months. The buccal tissue disclosed a cobblestone-appearance, combined with atypical fissures and rhagades in the anogenital region. Histopathological examination of lip and anogenital biopsy specimens revealed a granulomatous inflammatory reaction. Therefore, the clinical findings were interpreted as the primary manifestation of Crohn's disease. In the differential diagnosis Melkersson-Rosenthal's syndrome was also taken into consideration.
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