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  • Title: In vivo release of cholecystokinin-like immunoreactivity in rat frontal cortex under freely moving conditions.
    Author: Takita M, Tsuruta T, Oh-hashi Y, Kato T.
    Journal: Neurosci Lett; 1989 May 22; 100(1-3):249-53. PubMed ID: 2761773.
    Abstract:
    Release of cholecystokinin-like immunoreactivity (CCK-LI) was measured in rat medial prefrontal cortex in vivo by brain dialysis and enzyme immunoassay under freely moving condition. Perfusion of 50 mM K+ resulted in the increase of CCK-LI in the dialysate. The data on high-performance liquid chromatography (HPLC) of the dialysate showed that the increase of the CCK-LI was mainly due to the increase of CCK octapeptide sulfate itself. In the preliminary experiments, we applied this brain dialysis method for determination of CCK-LI release with drug treatment. After treatment with sulpiride (i.p.), a D2 dopamine receptor antagonist, a significant increase of CCK-LI was observed, indicating that this brain dialysis technique is applicable to detect change in the level of CCK-LI release after a certain drug treatment.
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