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  • Title: Delayed hemolytic transfusion reactions in sickle cell anemia.
    Author: Rao KR, Patel AR.
    Journal: South Med J; 1989 Aug; 82(8):1034-6. PubMed ID: 2762885.
    Abstract:
    Delayed hemolytic transfusion reaction (DHTR) developed in three patients with sickle cell anemia seen over an 18-month period at Cook Country Hospital. The DHTR was associated with severe pain crisis, with spherocytic hemolytic anemia, a positive direct antiglobulin test result, previously undetected erythrocyte alloantibodies, and disappearance of Hb A on cellulose acetate electrophoresis. Delayed hemolytic transfusion reactions may be more common than is generally recognized and should be considered when a patient has a sickle cell pain crisis shortly after receiving a transfusion.
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