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  • Title: Identification of Circulating MiR-25 as a Potential Biomarker for Pancreatic Cancer Diagnosis.
    Author: Deng T, Yuan Y, Zhang C, Zhang C, Yao W, Wang C, Liu R, Ba Y.
    Journal: Cell Physiol Biochem; 2016; 39(5):1716-1722. PubMed ID: 27639768.
    Abstract:
    BACKGROUND: The aim of this study was to identify novel microRNAs for potential use in the diagnosis of pancreatic cancer (PaC). METHODS: A total of 1063 serum samples from 303 patients with PaC were collected, and the expression level of miR-25 was measured using quantitative real-time PCR (qRT-PCR). RESULTS: We found that miR-25 had significant diagnostic value for the differential diagnosis of PaC in normal controls with an AUC (the area under the ROC curve) of 0.915 (95% CI: 0.893-0.937) that was significantly higher compared with an AUC of 0.725 for serum tumor marker carcinoembryonic antigen (CEA) and an AUC of 0.844 for CA19-9. CONCLUSIONS: These data suggest that serum miR-25 has strong potential as a novel biomarker for the early detection of PaC.
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