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  • Title: A highly selective fluorescent probe based on coumarin for the imaging of N2H4 in living cells.
    Author: Chen S, Hou P, Wang J, Liu L, Zhang Q.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2017 Feb 15; 173():170-174. PubMed ID: 27643466.
    Abstract:
    A turn-on fluorescence probe for highly sensitive and selective detection of N2H4 was developed based on hydrazine-triggered a substitution- cyclization-elimination cascade. Upon the treatment with N2H4, probe 1, 4-methyl-coumarin-7-yl bromobutanoate, displayed a remarkable fluorescence enhancement (25-fold) with a maximum at 450nm. This probe can quantitatively detect N2H4 with a extremely low detection limit as 7×10-8M. Moreover, cell imaging experiments have indicated that probe 1 has potential ability to detect and image N2H4 in biological systems.
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