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  • Title: Freeze fracture analysis of the axolemma of cultured dorsal root ganglion neurons in the absence of Schwann cells.
    Author: Bigbee JW, Foster RE.
    Journal: Brain Res; 1989 Aug 07; 494(1):182-6. PubMed ID: 2765918.
    Abstract:
    The distribution of intramembranous particles within the axolemma of cultured dorsal root ganglion neurons was determined by freeze-fracture microscopy. Utilizing culture conditions which eliminate Schwann cells, the particle distribution of the P-face, 735 +/- 119 microns2, and E-face, 100 +/- 39 microns2 resembled that of pre- and non-myelinated axons in vivo and no node-like E-face particle patching was seen. These results indicate that cultured neurite development is similar to that seen in vivo and that axons maintained in a glial-free environment do not develop nodal, E-face membrane specializations.
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