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  • Title: Induction of rat liver glutathione transferase subunit 7 by lead nitrate.
    Author: Di Ilio C, Aceto A, Columbano A, Ledda-Columbano GM, Federici G.
    Journal: Cancer Lett; 1989 Aug; 46(3):167-71. PubMed ID: 2766257.
    Abstract:
    The effect of a single dose of lead nitrate (10 microM/100 g body wt), a hepatic mitogen, on rat liver glutathione transferase (GST) subunit expression was investigated. Using SDS-polyacrylamide gel electrophoresis and Western blot technique evidence for the induction of GST 7-7 is shown. This occurrence is identical to that observed in preneoplastic nodules generated in rat liver by different models of chemical carcinogenesis, suggesting that lead nitrate may be a very simple model for investigation of the mechanism of glutathione transferase 7-7 gene expression in chemical hepatocarcinogenesis.
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