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  • Title: Methotrexate: studies on cellular metabolism. II--Effects on mitochondrial oxidative metabolism and ion transport.
    Author: Yamamoto N, Lopes LC, Campello AP, Klüppel ML.
    Journal: Cell Biochem Funct; 1989 Apr; 7(2):129-34. PubMed ID: 2766470.
    Abstract:
    Effects of methotrexate (MTX) on mitochondrial oxidative metabolism and ion transport were studied. MTX decreases the membrane potential (delta psi) upon energization of the mitochondrial membrane by NAD+-linked substrates and decreases the amplitude and velocity of swelling induced by glutamate and alpha-ketoglutarate. MTX also has an inhibitory effect on the activities of the oxidation enzymes of NAD+-linked substrates without interfering with the oxidation systems of FAD-linked substrates. The effects of MTX could be interpreted as a consequence of a decrease in the ionic conductivity of the mitochondrial inner membrane.
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