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  • Title: Altered erythrocyte cation permeability in familial pseudohyperkalaemia.
    Author: Dagher G, Vantyghem MC, Doise B, Lallau G, Racadot A, Lefebvre J.
    Journal: Clin Sci (Lond); 1989 Aug; 77(2):213-6. PubMed ID: 2766660.
    Abstract:
    1. Erythrocyte cation transport pathways have been investigated in a family with pseudohyperkalaemia. 2. Ouabain- and bumetanide-resistant Na+ and K+ effluxes in three pseudohyperkalaemic patients were not different from those of control subjects when assessed at 37 degrees C. 3. When the temperature was decreased to 20 degrees C and 9 degrees C, K+ passive permeability markedly increased and Na+ permeability remained unchanged in these patients. In contrast, in control subjects a reduction in temperature caused a marked reduction in Na+ and K+ passive permeability. 4. These findings could account for the marked increase in plasma K+ concentration observed at subphysiological temperatures. 5. The Na+-K+ co-transport pathway was reduced in all members of the family, but the Na+-K+ pump was reduced in only two of them. These alterations were independent from the pseudohyperkalaemic state.
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