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  • Title: Crystalline keratopathy due to intravenous immunoglobulin in a 12-year-old girl with Kawasaki disease.
    Author: Viswanathan V, Agashe P, Jain V, Nair AG.
    Journal: J AAPOS; 2016 Oct; 20(5):466-468.e1. PubMed ID: 27667371.
    Abstract:
    Kawasaki disease (KD) is an acute, self-limiting, medium-vessel vasculitis that occurs predominantly in young children. The treatment of KD consists of intravenous immunoglobulin (IVIG) along with aspirin and, in IVIG-resistant cases, corticosteroids. Crystalline keratopathy with corneal deposition of the immunoglobulin is a rare complication of IVIG therapy. We report the case of a 12-year-old girl who received IVIG for KD and developed visual complaints, which were attributable to crystalline keratopathy and corneal edema. Cessation of IVIG and treatment with topical and systemic corticosteroids reversed the finding. At final follow-up, vision in both eyes was normal.
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