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  • Title: α-Glucosidase Inhibitors from Preussia minimoides ‡.
    Author: Rangel-Grimaldo M, Rivero-Cruz I, Madariaga-Mazón A, Figueroa M, Mata R.
    Journal: J Nat Prod; 2017 Mar 24; 80(3):582-587. PubMed ID: 27673367.
    Abstract:
    Extensive fractionation of an extract from the grain-based culture of the endophytic fungus Preussia minimoides led to the isolation of two new polyketides with novel skeletons, minimoidiones A (1) and B (2), along with the known compounds preussochromone C (3), corymbiferone (4), and 5-hydroxy-2,7-dimethoxy-8-methylnaphthoquinone (5). The structures of 1 and 2 were elucidated using 1D and 2D NMR data analysis, along with DFT calculations of 1H NMR chemical shifts. The absolute configuration of 1 was established by a single-crystal X-ray diffraction analysis and TDDFT-ECD calculations. Compounds 1-4 significantly inhibited yeast α-glucosidase.
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